Can a corrupted save file cause Wii Error Code 51330?

Yes, a corrupted save file is a common cause of Error Code 51330. Save files store game progress and system settings. If these files become corrupted due to power outages, improper shutdowns, or other issues, the Wii might not be able to boot properly and will display the error. Deleting the corrupted save file (after backing up important saves, if possible) and restarting the Wii might resolve the issue.