What software do most professional digital comic artists use?

The industry standard is often a combination of tools. Adobe Photoshop remains incredibly popular for painting, coloring, and editing. Clip Studio Paint is favored for its comic-specific features like paneling tools, perspective rulers, and natural brush feel. Procreate on iPad is gaining traction for its portability and intuitive interface. Some artists also use software like Corel Painter or Krita (free and open-source).