What should I do if I consistently receive an Outlook Web App error 500 after a recent Office 365 update?

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What should I do if I consistently receive an Outlook Web App error 500 after a recent Office 365 update?
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If the error 500 started immediately after an Office 365 update, it's likely related to the update. Check the Office 365 Message Center for known issues related to the update. Microsoft often releases fixes for update-related problems. Contact Microsoft Support if the issue persists, providing details about the update and the error.